Phenyl-2-Nitropropene (P2NP) is a chemical intermediate used in the synthesis of various organic compounds, including amphetamines and methamphetamines. Its chemical structure consists of a phenyl group attached to a nitroalkene moiety, making it a versatile precursor in the field of organic chemistry.

Chemical Structure and Composition:

At the molecular level, P2NP has the molecular formula C9H9NO2 and a molar mass of 163.17 g/mol. Its chemical structure features a nitroalkene functional group, which undergoes reduction reactions to yield a wide range of substituted phenethylamines. P2NP is commonly utilized in clandestine laboratories for the illicit production of psychoactive substances due to its availability and ease of synthesis.

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Physical Properties:

Physically, P2NP typically appears as yellow to orange crystalline solid with a characteristic odor. It is sparingly soluble in water but soluble in organic solvents such as ethanol and ether. P2NP exhibits a melting point range between 70°C to 80°C, depending on its purity and crystalline form.

Chemical Behavior and Reactions:

In terms of chemical behavior, P2NP serves as a precursor in the synthesis of various illicit drugs, including amphetamines and methamphetamines. It undergoes reduction reactions, commonly employing reagents such as aluminum amalgam or hydrogen gas in the presence of a catalyst, to yield the desired amphetamine derivatives. Additionally, P2NP can participate in condensation reactions with primary amines to form imines, which can further undergo reduction to produce secondary amines.

Biological Effects and Pharmacology:

Due to its role as a precursor in the synthesis of psychoactive compounds, P2NP itself does not exhibit significant pharmacological activity. However, its derivatives, such as amphetamines and methamphetamines, exert potent stimulant effects on the central nervous system. These substances increase the release of monoamine neurotransmitters, including dopamine, norepinephrine, and serotonin, leading to enhanced arousal, euphoria, and cognitive function.


In conclusion, Phenyl-2-Nitropropene (P2NP) is a versatile chemical intermediate used in the illicit synthesis of psychoactive substances. Despite its lack of direct pharmacological effects, P2NP plays a crucial role in the clandestine production of amphetamines and methamphetamines, highlighting the importance of regulating its availability and distribution.

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